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**Increase in N.Z Post Delivery Rates** July 2023
Due to inflationary pressures, new Rates are as follows:
Economy Rate, tracked @ $8.
**Due to some unacceptable increases in target delivey time frames, arising from increased Christmas mail volumes @ N.Z Post, we are using N.Z Courier Delivery only, until further notice.**
Courier Rate, tracked @ $10. (*Fastest Delivery)
Rural Delivery Rate @ plus+ $5.50
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*p & p = $7. *Rural Delivery = $12. *Add an extra $2. to upgrade to Priority Delivery.
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*Price List & Specials - HERE
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*F.A.Q - Re prices/products/purchase - HERE
Contact: northlandsalvia@gmail.com
*Salvinorex Double Action herbal remedy = Salvia divinorum + beta Caryophyllene.
Salvinorex Tincture, Oil, E-Juice-VG Juice:
*Available as an Extra Virgin Olive Oil 30x Liquid Extract OR
a (VG Juice) Vegetable Glycerine 30x Liquid Extract.
5 ml Sampler 30x strength Salvinorex Herbal Tincture, Oil, VG Juice:
5 ml @ $30. *plus p & p.
20 ml 30x strength Salvinorex - Herbal Tincture Oil, VG Juice:
20 ml @ $119. *plus p & p.
*20 ml Special get an extra 5 ml Free! (25 ml) Save $30.
*25 ml (Special) = *Sold Out*
100 ml 30x strength Salvinorex - Herbal Tincture Oil, VG Juice:
100 ml @ $499. *plus p & p. Special +FREE Post Economy Rate, Save $
*p & p = $7. *Rural Delivery = $12.
NEW! Salvinorex dried herb & dried herbal extract for use in Dry Herb Vape Devices.
Salvinorex dried natural Leaves:
4 grams @ $, plus p & p.
8 grams @ $ plus p & p.
12 grams @ $ plus p & p.
*Salvinorex Leaves can be used to make Salvinorex Tea too.
Salvinorex dried herbal extract:
5x = extracted from 5 g of Salvia herbs.
10x = extracted from 10 g of Salvia herbs.
15x = extracted from 15 g of Salvia herbs.
20x = extracted from 20 g of Salvia herbs.
30x = extracted from 30 g of Salvia herbs.
Dried Herbal Extract Pricing: (per g, gross)
5x:
1 gram @ $ per g, (gross) *plus p & p.
*5x Special – 2 g (gross) Salvinorex 5x @ $. *plus p & p. Save $
10x:
1 gram @ $p er g, (gross) *plus p & p.
15x:
1 gram @ $ per g,(gross) *plus p & p.
20x:
1 gram @ $ per g, (gross) *plus p & p.
30x:1 gram @ $ per g, (gross) *plus p & p.
*p & p = $8 Economy tracked, OR $10. Courier, tracked (fastest delivery) Rural Delivery = +plus$5.50.
BUY NOW: Payment via Online Banking.
Contact: northlandsalvia@gmail.com
E Mail
LINK@ Antinociceptive effects of Salvia divinorum and bioactive salvinorins in experimental pain model
"S. divinorum extract produced a dose-dependent antinociceptive effect at central and peripheral levels in pain models. The effect of the extract was observed due to the presence of salvinorins, mainly salvinorin A. Antinociceptive effect of S. divinorum involved both the serotonin 5-HT1A and opioids receptors as inhibitory neurotransmission depending on the type of nociception."
*antinociceptive = the action or process of blocking the detection of a painful or injurious stimulus by sensory neurons.
Therapeutic Potential of Salvia divinorum:
KOR agonists such as SA (Salvinorin A) have applications for multiple ailments, and SA is extremely affine, potent, and precise when it comes to binding to these brain receptors.
Some of the valuable medications that could be developed from S. divinorum are:
• Safe analgesics without addictive properties:
The efficacy of SA as an analgesic has been demonstrated in animal studies (Guida et al., 2012).
In current medical practice, sometimes very powerful analgesics like morphine are used, which are habit forming and produce dependence. This is not the case with SA. In fact, research has shown that SA has anti-addictive properties
(Serra et al., 2015).
• Anti-inflammatories:
It has been demonstrated in animal studies that SA has ultra-potent effects on macrophages via the KOR and CB1 receptors and exerts an important attenuation of inflammation and antipruritic effects.
SA inhibits intestinal motility and reduces abdominal pain in the irritable bowel syndrome. In recent studies with mice, SA has been shown to inhibit the leukotriene-mediated inflammatory response. Leukotrienes are crucial in various autoimmune and inflammatory conditions such as urticaria, bronchial asthma, allergic rhinitis, and cardiovascular problems (Aviello et al., 2011; Rossi et al.,2016.
• Antidepressants:
Animal studies have shown antidepressant properties of SA, and it has been proposed as an ideal candidate for the treatment of major depressive disorder (Taylor & Manzella, 2016).
Regarding human subjects, K. R. Hanes (Hanes, 2001, 2003), in Australia, presented a case report of a 26-year-old woman with a long treatment-resistant depression who showed improvement after taking sub-psychoactive oral doses of S. divinorum leaves.
The patient chewed and held in the mouth 0.5 to 0.75 grams of dry leaf for 15–30 min, two or three times per week. The patient also claimed to benefit from occasional psychoactive doses of S. divinorum consisting of 2–4 g of leaves taken following the same method as the previous one.
Dr. Hanes reported on the patient’s total remission of depressive symptoms in the past 6 months, in addition to a considerable improvement in self-esteem and psychospiritual development.
Later, Hanes wrote a follow-up report in which he described six additional patients who reported obtaining complete remission of symptoms in treatment-resistant depression using the leaves of S. divinorum. Maqueda, A. E. (2018). The Use of Salvia divinorum from a Mazatec Perspective.
Salvinorex is a potent Salvia divinorum-Caryophyllene herbal tincture & Oil, that may bring relief to sufferers of acute pain & spasticity, often associated with debilitating conditions such as Multiple Sclerosis, Spinal Cord Injury, & Complex Regional Pain Syndrome C.R.P.S .
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Salvia divinorum is antinociceptive, i.e, it reduces sensitivity to painful stimulii. It is also a very powerful anti inflammatory. A significant body of evidence also suggests its efficacy in treating neurological disorders.
Sublingual dosing of Salvia divinorum tinctures & Oils DOES NOT present the same intoxicating effects sometimes associated with this miraculous plant! It can be used to micro dose on an as needed basis.
beta Caryophyllene, the Cannabinoid Super Molecule!
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| Buy Online Salvinorex 30x Liquid Extract New Zealand N.Z |
Cannabinoid type 2 receptor (CB2R)-mediated pharmacological activities and therapeutic potential of β-caryophyllene (BCP):
LINK@ Table 1. The in vivo studies demonstrating cannabinoid type 2 receptor (CB2R)-mediated therapeutic potential of β-caryophyllene (BCP).
LINK@ Table 2. The in vitro studies demonstrating cannabinoid type 2 receptor (CB2R)-mediated therapeutic potential of β-caryophyllene (BCP). *Obesity & related complications et al.
LINK@ Recent advances in the relationship between obesity,inflammation, and insulin resistance
It now appears that, in most obese patients, obesity is associated with a low-grade inflammation of white adipose tissue (WAT) resulting from chronic activation of the innate immune system and which can subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes.
Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications:
β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells:
Caryophyllene (BCP) is a potent analgesic & anti inflammatory, through its activity at the CB2 Cannabinoid Receptors.
Caryophyllene is a non psychoactive Cannabinoid, active only at the CB.2 Cannabinoid Receptors, that can be sourced from some non Cannabis plants, but at significantly higher concentrations than the Cannabis Plant.
See LINK@ CB.2RA Cannabinoid
β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
Studies have indicated the potential efficacy of Caryophyllene in suppressing motor paralysis & neuro inflammation associated with Multiple Sclerosis. (Alberti et al)
See:
β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor
Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis
" (this) study represents significant implications for clinical
research and strongly supports the effectiveness of BCP as a novel molecule to
target in the development of effective therapeutic agents for MS. "
See: Multiple sclerosis and other neuroinflammatory diseases
LINK@ Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway
results suggest that inhaled BCP is incorporated into the aortic wall and prevents nicotine-induced degeneration of the aorta via a CB2 receptor-dependent pathway.
See: Cannabimimetic phytochemicals in the diet – an evolutionary link to food selection and metabolic stress adaptation?
' The best studied phytochemical is β‐caryophyllene (BCP), which has been independently shown to exert numerous CB2receptor‐mediated cannabimimetic effects......'
See: Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation
" The sesquiterpene hydrocarbon (E)-β-caryophyllene (BCP) is one of the most studied and promising natural compounds In recent years, modulatory and pharmacological effects of BCP have been demonstrated in numerous organs such as liver kidney and brain. BCP has been reported to exert therapeutic effects as antioxidant, anti-inflammatory and anticancer. Importantly, BCP has been identified as a fully selective agonist of CB2 cannabinoid receptors, one of the key members of the endocannabinoid system (ECS)."
Spasticity is a condition in which muscles tense reflexively
and resist stretching. It is caused by an imbalance of signals from the central nervous system (brain and spinal cord) to the muscles.
This
imbalance is often found in people with cerebral palsy, traumatic brain
injury, stroke, multiple sclerosis, and spinal cord injury.
Salvia Users with multiple sclerosis may experience a reduction in both pain and spasticity.
Coping with stiff, aching, cramping muscles is a way of
life for most of the 2.5 million people in the world who have multiple
sclerosis.
Many of the 15 million people worldwide, with spinal cord injuries also suffer from the same symptoms, which cause pain, limit movement, and rob people of much needed sleep.
Salvinorin A acts as an agonist, binding to the kappa opioid receptor (KOR) a protein, activating that receptor to produce a biological response.
Salvinorin A/ Salvinorin A, is a uniquely potent and highly selective kappa-opioid receptor agonist, and as such, it has tremendous potential for the development of a wide variety of valuable medications. The most promising of these includes safe non-addictive analgesics.(Roth et al., 2002).
Some of the symptoms of multiple sclerosis include depression & unstable mood.
The potential anti anxiety & anti depressant effects of Salvia divinorum have been widely reported in medical studies.
Karl R. Hanes, Ph.D of the Cognitive - Behavioural Treatment Centre, Melbourne, Victoria, Australia reported that:
“Although it is too early to draw definitive conclusions regarding the antidepressant potential of Salvia divinorum, initial results are promising, with the majority of patients reporting lasting benefits from their use of this herb. In addition to significantly reduced scores on quantitative measures of depression, some of the reported benefits of the herb include mood enhancement and increased feelings of relaxation and self-awareness."
See LINK@ Salvia divinorum: Clinical & Research Potential
Safety:
In the contemporary medical context, testing is showing that some of the compounds contained in Salvia divinorum herb have much milder side effects than traditional pharmaceutical treatments for multiple sclerosis & spinal cord injury.
We are able to offer our Salvia divinorum-Caryophyllene based Oils & tinctures at a much reduced cost, comparative to some other alternatives.
Oil & Tincture
dosing via sublingual absorption is slow release, & is
ideal for micro dosing on an as needed basis.
Salvia divinorum - Potential treatment for Complex Regional pain Syndrome C.R.P.S?
LINK: Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection
Salvia divinorum - Potential treatment for Parkinsons Disease?
Salvinorin A, the active constituent in the Salvia divinorum herb also acts as a D2DR partial agonist.
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
Dopamine
receptors are implicated in many neurological processes, including
motivation, pleasure, cognition, memory, learning, and fine motor
control, as well as modulation of neuroendocrine signaling. (A type of
cell signaling involving the release of a hormone from a nerve cell that
has an effect on another cell.)
Abnormal dopamine receptor
signaling and dopaminergic nerve function is implicated in several
neuropsychiatric disorders, including Dementia, Parkinson’s Disease
& Alzheimer's Disease.
Parkinson’s is a progressive neurodegenerative condition. It is caused by insufficient quantities of dopamine in the brain.
Dopamine
enables quick, well-coordinated movement. When dopamine levels fall,
movements become slow and awkward. Parkinson’s has both motor and
non-motor symptoms.
This makes the development of medications
containing Dopamine receptor Agonists, common neurologic drug targets by
pharmaceutical companies.
Anecdotally, Salvinorin A stimulates a
precisely targeted area of the brain. the Dopamine receptor D2, which
blocks the abnormal nerve signals being transmitted by areas in the
brain that are not functioning properly.
As a result, the
symptoms of Parkinsons may be better controlled, which may translate to a
sufferer being able to reduce the medication they need to take for their
condition.
See: β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 mice through CB2 receptor activation and the PPARγ pathway
" results demonstrate that the anti-inflammatory effect of the sesquiterpene β-caryophyllene involves CB2 receptor activation and the PPARγ pathway and suggest β-caryophyllene as an attractive molecule for the development of new drugs with therapeutic potential for the treatment of Alzheimers Disease."
Salvia divinorum - Potential treatment for Tourettes Syndrome?
Salvinorin A, the active constituent in the Salvia divinorum herb is a Kappa Opioid Receptor Agonist.
At low doses Spiradoline, a Kappa Opioid Receptor Agonist was reported to decrease tics in patients with Tourette's syndrome. Unfortunately, Spiradoline's significant side effects such as dysphoria and hallucinations have stopped it from being used clinically.
Taken sublingually, which is the traditional Mexican Mazatec way to dose, Salvinorex tincture, which targets the Kappa Opioid Receptors & CB2 Cannabinoid Receptors, may bring relief to Tourette subjects, without such deleterious side effects.
See PDF@ HERE
Our 30x Strength Liquid Extracts: 5 ml, 20 ml, 100 ml, 500 ml, 1 Litre. *Extra Virgin Olive Oil OR VG – Vegetable Glycerine: Salvia divinorum, Phyto-CANNAPLUS+ 30X Liquid Extract VG-Juice, CB.2RA Cannabinoid Oil beta Caryophyllene Liquid Extract, CB.2-K.O.R Salvia + Cannabinoids + Terpenes, Marali, Xochipilli, SmokeStop, Mexican Marigold, Saints & Sinners Salvia + Mexican Marigold. MethQuit Salvex *You can Sublingually dose (tincture dropper under the tongue) all our VG Juice Liquid Extracts too.
CB2R.A Cannabinoid Oil C.B.D CBD Tincture VG Juice & Balm N.Z
CB.2RA Cannabinoid Profile:
There are many commercially available
Cannabis preparations rich in β-caryophyllene
(BCP), including:
Bedrocan®, Sativex®, Marinol®, Bedrobinol®, Namisol®, Arvisol®, Fenoxidol™,
Epidiolex® etc. Hebaallah Mamdouh Hashiesh et al, 2021
beta Caryophyllene (BCP) is a major component in Cannabis & some non Cannabis Plants, & is classified as a dietary cannabinoid.
See Link: Strain Profile White Widow Cannabis (Tilray)
See Link: Terpene Profile Caryophyllene (Tilray)
The phytocannabinoid caryophyllene, also known as beta-caryophyllene or BCP, is crucial to not only the smell and taste of Cannabis, but also the medical benefits and different effects strains provide. There are over 100 known cannabinoids & terpenoids in the cannabis plant, but BCP is one of the most prominent.
C.B 2 R.A - Cannabinoid Oil also contains the primary Terpenes: Myrcene, Linalool, Pinene, Humulene, Trans-nerolidol, & more!
The Cannabinoid BCP beta Caryophyllene, an attractive compound for chronic pain (both inflammatory and neurogenic)
The Cannabinoid BCP beta Caryophyllene is an attractive compound for chronic pain (both inflammatory and neurogenic) due to its direct action on CB2R without creating a tolerance, as demonstrated in an animal model of neuropathic pain [30].
Remarkably, the researchers concluded that the effect of BCP became stronger during the treatment period.
This is significant considering drug tolerance after prolonged use is observed with other analgesic therapies and may require increased dosage, which may accelerate tolerance and further reduce the effects of a therapeutic substance.
BCP exerts potent anti-inflammatory effects when taken orally, which may be explained by its ability to simultaneously inhibit pathways (toll-like receptor complex CD14/TLR4/MD2) that increase the production of proinflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-⍺), reduce immune-related inflammation, and synergize the µ-opioid receptor pathways.
Preclinical models demonstrate that BCP can reduce inflammation in a variety of bacterial-caused, eosinophil-related, and neuropathic inflammatory conditions [32].
It can also enhance the effects of other pain medications like morphine, making it a promising candidate to reduce effective drug dose and therefore potential drug dependence and tolerance.
In this way, it modulates pain signaling pathways in a manner that may enhance, and not compete with, the benefits of other pain-or inflammation-relieving substances. Scott A. Johnson et al, 2020.
Link: New Insights and Potential Therapeutic Targeting of CB2 Cannabinoid Receptors in Central Nervous System Disorders
Studies done on the CB2 Receptors as a therapeutic target for
treating different disorders revealed the important potential role of
CB2Rs in certain Central Nervous System (CNS) disorders.
This review addresses recent advances on the role of CB2Rs
in neuropsychiatric and neurodegenerative disorders, including, but not
limited to, anxiety, depression, schizophrenia, Parkinson's disease
(PD), Alzheimer's disease (AD), Huntington's disease (HD) and addiction.
Highest Potency Black Label Salvia divinorum Herbal Tincture & Oil:
Our Black Label 100x Salvia divinorum tinctures Oils & VG Juice are a potent, aged, 'Super Potentiated' high strength herbal remedy that provides a long duration dose that may bring relief for those suffering physical pain or emotional crisis.
Tincture & Oil dosing via sublingual absorption is slow release, & is ideal for micro dosing on an as needed basis.
Extracted from Salvia divinorum herb, this optimum strength, Salvia divinorum tincture, Oil VG Juice, may 'temper' the effects of physical pain or emotional turmoil.
Black Label 100x Salvia divinorum Tincture, Oil, VG Juice.
*P.O.E = Price on Enquiry.
*p & p = $7. *Rural Delivery = $12.
BUY NOW: Payment via online banking.
Contact: northlandsalvia@gmail.com
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Terms of Trade & Conditions:
The statements made by Northland Salvia
have not been evaluated by the New Zealand Ministry of Health.
These products are not intended to diagnose, treat, cure, or prevent
any disease.
We are not advising or prescribing herbs, herbal extracts, or herbal remedies, for any specific medical
conditions, or for any specific uses.
Consult your doctor, practitioner, and/or pharmacist for any health problems and before using any herbs, herbal extracts, or herbal remedies, or before making any changes in prescribed medications.
R.18 New Zealand Customers Only - Proof of Age Required.
By using this site, you certify that you are aged 18 years old and over, & that any Salvia divinorum Herbal Remedies purchased from us, are intended for lawful purposes only.
Under New Zealand law, our Salvia divinorum Herbal Remedies may only be purchased for legal herbal use.
Our herbs may assist those seeking a natural plant based herbal remedy, with analgesic, sedative, & anti inflammatory effects.
We request *Proof of Age before we can confirm your Order. This includes: an emailed scanned copy or digital photo of your N.Z driver's licence, passport or HAANZ 18+ card.
You will then be a Verified NorthlandSalvia Customer.
Individual results in the use of our products may vary, depending on the Individual's tolerance, sensitivity & metabolism.
By purchasing ANY of our herbal remedies, you agree to ALL our terms & conditions.
Returns Policy:
Due to the potential for adulteration of our herbal remedies, & thereby risk to any of our Customers, please be aware that we DO NOT accept any returns where our herbal products have been used, partially used, or the products original N.Z Post sealed bag has been opened.
Refunds may be issued for the value of the returned product, & DO NOT include the cost of shipping, or return shipping, as this is a cost we cannot recover.
Under New Zealand law, our herbal remedies may only be purchased for legal herbal use.
All our herbal products are available for purchase on the basis of their efficacy
as herbal remedies.
Our herbs may assist those seeking a natural plant based traditional herbal remedy,
with potential anti addiction, analgesic, sedative, & anti inflammatory effects.
We advocate responsible use of our herbs.
By purchasing ANY of our herbal remedies, you agree to ALL our terms & conditions.
Our full terms & conditions - HERE
Individual results
in the use of our products may vary, depending on the Individual's
tolerance, sensitivity & metabolism.
By purchasing any of our Herbal Remedies, you agree to all our terms & conditions.
Returns Policy:
Due to the potential for adulteration & thereby risk to any of our
Customers, please be aware that we DO NOT accept any returns where our
herbal products have been used, partially used, or the items original sealed N.Z post bag has been
opened.
100% Natural, 100% Homegrown.
*BUY NOW. *Payment via online banking.
Contact: northlandsalvia@gmail.com
Multiple Sclerosis, Spinal Cord Injury, & Complex Regional Pain Syndrome C.R.P.S .
